349900
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SKU
DD-IM-349900
| VDRC Id | 349900 |
|---|---|
| Library | DD-Im |
| Sub-Category | mutants |
| Status | available |
| Comment | BL1. A deletion of Relish (which also affects a nearby gene). The ebony marker of the original stock (Dan Hultmark‘s lab) was removed by recombination with an Oregon stock. The Rel[E20] mutation was then introgressed in the w[1118] DrosDel genetic background. Rel[E20] lack a functional Imd pathway and are susceptible to Gram negative bacterial infection. The transcription factor Relish may also be involved in the immune defence against viruses downstream of cGas-like, Sting and IKK (Cai et al., Curr Opin Immumol (2022)). |
| Construct Id | 349900 |
| Genotype | w[1118]; ; Rel[E20] |
| Gene Symbol | Rel |
| Gene Name | Relish |
| Synonyms | DrosDel Immunity panel NF-KB NF-kappaB NF-κB NFkappaB NFκB Nuclear Factor-kappa-B p110 Nuclear factor NF-kappa-B p110 subunit REL RELI RELISH Rel Rel-p110 Rel/NF-kappaB Rel/NF-κB Rel1 Rel49 RelA Relish |
| Keywords | DrosDel Immunity panel |
| Inserted Chromosome | 3 |
| Viability | viable |
| Publication | Ferreira et al., PLoS Pathog (2014) |
| Provider Scientist | Bruno Lemaitre with the help of Mark Hanson |
| Provider Organization | EPFL |